Thiolsulfonate functionalized polystyrene resin: Preparation and applicationin the isolation and identification of electrophilic mutagens
Wu E , Robert M. Carlson
DOI:
Received February 01, 2007,Revised August 13, 2007, Accepted , Available online
Volume 19,2007,Pages 1520-1527
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A new approach for isolation and identification of elecrtophilic mutagens from complex matrix was developed. Thiosulfonic anion
was immobilized onto polystyrene beads and used as separation media. Potassium polystyryl-thiosulfonate, prepared from polystyrylsulfonyl
chloride and KHS, was observed to selectively react with model electrophilic mutagens such as alkyl halides, -chloroketones
and -chloroesters to produce polystyryl-thiosulfonic esters. After separation from other nonreactive organic compounds, the beads
then reacted with ethanethiol to produce unsymmetrical ethyl disulfides which are easily detected by GC/MS. For one mutagenic
compound, only one unsymmetrical disulfide was found to contain its structure part. Thus, the structure of the parent mutagens could
be deduced from that of the unsymmetrical disulfides. The degree of functionalization of the potassium polystyryl-thiosulfonate resin
was 1.11 mmol/g. Its reactivity was discussed and its recycling method was reported here.
