Environmental biology

The acute lethality and endocrine e ect of 1,2,3,7,8-PeCDD in juvenilegoldfish (Carassius auratus) in vivo

YANG Yongbin , LIU Zhengtao , ZHENG Minghui , ZHAO Yanyan , WANG Liang , SUN Wei , XIAO Feng


Received April 03, 2007,Revised May 09, 2007, Accepted , Available online

Volume 20,2008,Pages 240-245

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1,2,3,7,8-PeCDD was administrated to juvenile goldfish (Carassius auratus) by peritoneal injections to explore the acute lethality and endocrine e ects of 1,2,3,7,8-PeCDD in vivo. The value of acute median lethal dosage (LD50) of 1,2,3,7,8-PeCDD was determined in acute lethality tests. The endocrine e ect of 1,2,3,7,8-PeCDD, whose exposed concentrations were determined based on the LD50 (1.84 mg/kg), was studied by measuring the plasma vitellogenin (Vtg) content in juvenile male goldfish with enzyme-linked immunosorbent assays (ELISA). Due to its significant induction of the plasma Vtg after one week’s exposure in vivo in the 1/2 LD50 and LD30 groups, 1,2,3,7,8-PeCDD might be one of the important contributors to the estrogenic e ect of PCDDs in the environment. The values of 1/2 LD50 and LD30 were within the range of the e ective dosages of 1,2,3,7,8-PeCDD, indicating that there was a certain relationship between the estrogenic e ective dosages and the LD50.

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