Environmental health and toxicology

Potential neoplastic e ects of parathion-methyl on rat liver

M. Nisa Unaldi Coral , Sonay Ucman , Hasan Yildiz , Haydar Oztas , Semih Dalkilic


Received May 06, 2008,Revised September 23, 2008, Accepted , Available online

Volume 21,2009,Pages 696-699

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The mutagenic and carcinogenic e ects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic e ect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.

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