Environmental health and toxicology

Chronic toxicity and cytotoxicity of synthetic pyrethroid insecticidecis-bifenthrin

WANG Cui , CHEN Fang , ZHANG Quan , FANG Zhuo


Received February 07, 2009,Revised April 08, 2009, Accepted , Available online

Volume 21,2009,Pages 1710-1715

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With the increasing use of synthetic pyrethroids (SPs), the significance of ecological safety and health risk is an emerging concern. In this study, we evaluated the chronic aquatic toxicity of cis-bifenthrin (cis-BF) in Daphnia magna and its cytotoxicity in Chinese hamster ovary (CHO) cells as well as human cervical carcinoma (Hela) cells. Chronic aquatic toxicity tests showed that cis-BF could significantly a ect the reproduction of D. magna. The lowest observed e ective concentration and the non-observed e ective concentration of cis-BF to D. magna were 0.02 and 0.01 g/L, respectively, and the chronic value was 0.014 g/L. The intrinsic rate of natural increase was significantly decreased (p < 0.05) to 0.02 g/L. The cytotoxicity assay demonstrated that cis-BF decreased cell viability in CHO and Hela cells in a concentration- and time-dependent manner. The IC50 values for Hela and CHO cells were 4.0 10??5and 3.2 10??5 mol/L, respectively. Together, these results indicated that cis-BF induced chronic toxicity in both aquatic invertebrate animals and mammalian cells. These findings assist in understanding the impact of SPs on health and environmental safety. Considering the wide spectrum of SPs, a more comprehensive understanding of the negative e ects is indispensible for planning future application and regulation of these pesticides.

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