TY - JOUR ID - 10.1016/j.jes.2021.08.025 TI - Urinary analysis reveals high Alternaria mycotoxins exposure in the general population from Beijing, China AU - Xiaoting Qiao AU - Gang Li AU - Jing Zhang AU - Jing Du AU - Yunjia Yang AU - Jie Yin AU - Hui Li AU - Jie Xie AU - You Jiang AU - Xiang Fang AU - Xinhua Dai AU - Bing Shao VL - 34 IS - 8 PB - SP - 122 EP - 129 PY - JF - Journal of Environmental Sciences JA - J. Environ. Sci. UR - http://www.jesc.ac.cn/jesc_en/ch/reader/view_abstract.aspx?file_no=S1001074221003296&flag=1 KW - Corresponding authors.;Biomonitoring;UPLC-MS/MS;Exposure assessment;Adults AB - Alternaria mycotoxins are of concern due to its adverse health effect, they affect various cereal crops and grain-based food along with modified forms that contribute to overall exposure. This study aimed to determine the frequency and level of exposure to Alternaria mycotoxins (tenuazonic acid, TeA; alternariol, AOH; alternariol monomethyl ether, AME; tentoxin, TEN; and altenuene, ALT) in human urine from Beijing adults. A total of 2212 urine samples were collected and analyzed for five mycotoxins using LC–ESI–MS/MS. More than 98% of the samples had at least one Alternaria mycotoxin detected. Among the mycotoxins, AME had the highest detection rate (96.0%), followed by TeA (70.5%). The calculated average daily intake values of AME (12.5 ng/kg b.w.) was 5 times the TTC value (2.5 ng/kg b.w.) set by the EFSA, indicating the potential health risks associated with mycotoxins. Immediate attention and subsequent actions should be taken to identify the sources of mycotoxins and the corresponding exposure pathways to humans in the investigated regions. ER -