Environmental health and toxicology

Cytotoxicity of lambda-cyhalothrin on the macrophage cell line RAW264.7

Quan Zhang , Cui Wang , Liwei Sun , Ling Li , Meirong Zhao


Received April 29, 2009,Revised December 01, 2009, Accepted , Available online

Volume 22,2010,Pages 428-432

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The wide use and wide-spectrum toxicity of synthetic pyrethroids (SPs) insecticides make them an emerging ecotoxicological concern. Some previous studies showed that SPs possessed cytotoxicity in some immune cells such as human lymphocytes and rat bone marrow. However, the cytotoxicity of SPs to macrophages, which are crucial to innate immunity, has not been explored. In the present report, we investigated a new pyrethroid insecticide, lambda-cyhalothrin (LCT), which may increase the generation of reactive oxygen species (ROS) and DNA damage levels and cause cytotoxicity in RAW 264.7 cells in dose- and time-dependent manners. The results for the first time implicated increased endogenous ROS and DNA damage as co-mediators of LCT-induced cytotoxicity in macrophages. Our results also suggested that macrophages were involved in synthetic pyrethroid-induced adverse immune e ects. Considering the ubiquitous environmental presence of SPs, this study provided new information relative to the potential long-term physiological and immunological e ects associated with chronic exposure to SPs. Hence, the potential immunotoxicity of SPs should be considered in assessing the safety of these compounds in sensitive environmental compartments.

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